I bought this printer because I was in a bind, and needed something that would work right out of the box... and I needed is FAST, to complete some orders within a deadline. I also needed something that would print Nylon well, and with no issues, again right out of the box. I use Prusa Mk3s for most of my production- And, if I'd have had time, would have just ordered another one of them. But- I didn't have time for it to arrive and to get it assembled. So, after reading reviews and doing some research, I bought this one.Don't want to read a long review? Here are the Pros and Cons-PROS--Prints well, right out of the box.-Easy, guided setup.-No assembly, testing, or tweaking-Easy to use touch screen interface, Web based 'cloud' printing through WIFI, and easy to use slicer included-Great US based customer support-Fully enclosed, VERY quiet.-All metal hotend can handle just about any filamentCons--Build area is on the small side-Designed to use Dremel filaments. You CAN use 3rd party, but you'll have to make some changes. Dremel spools are smaller than 'normal' spools.-A little tough to adjust settings while printingIf you still think it might be for you, read on!So- How easy is it REALLY to set up? From opening the box to starting the first print was less than 20 minutes, and most of that time was spent removing all the packing material. This machine is ready to go, right out of the box. All you really have to do (other than remove all of the packaging!) is to put the bed in place and load the filament. Oh, you have to plug it in, too...I switched it on, and it walks you through the setup, first connecting to your WiFi network. I loaded one of the included filament rolls. The printer does not have a self leveling bed, but it uses an assisted leveling process to get everything set. It's quick and painless, the printer tells you EXACTLY what to do. Since my first time leveling, I have not had to relevel the bed yet. I have checked it a few times, but it's always OK. You have several options to control the printer- Using the web interface, the touch screen, or via a USB connected computer. For the first print, I decided to just use one of the files that was preloaded in the printer, with the touch screen. You scroll through a couple of easy to navigate menus using the touch screen interface, hit start, and let it go. The first print turned out nice.For the next print, I used the web-based interface. There is a slicer online, but I chose to use the slicing software that came with the printer, The DigiLab Slicer. Those who are familiar with Cura will immediately recognize it- it's Dremel's own version. It is quick and easy to use, and like other versions of Cura allows you to do a lot of custom setting changes to tweak your prints as needed. I chose to do a 'benchy' so I could compare it to the others I have printed on my other printers. I uploaded it, and sent it to the printer via Dremel's online interface. The really cool thing about printing from the cloud is the video monitoring- I can check in on it any time i want to on my iPhone or computer. And, when the print is done, I get an Email that includes a time lapse video of the entire print. The Benchy turned out great. Not QUITE as nice as the ones that I print on my Prusas, but bear in mind i'm getting this quality of output right out of the box.So- Next thing to try is a more 'exotic' filament- Nylon. I've always had difficulty with nylon, and have avoided it. I read a lot of reviews about this printer that said it did a great job with Nylon. So, I loaded the included spool of Nylon filament and gave it a shot. The first thing that I printed was a simple wall hook. It printed very nicely- Almost flawless. The strength and flexibility of nylon prints is unbelievable. I'm really looking forward to using more of it.The printer is 'optimized' for using Dremel filaments- In fact, the filament spools have RFID chips in them that allow the printer to identify what kind of filament you have loaded. You are not restricted to only Dremel brand, though, it can also use other filaments as well. The Dremel uses a smaller spool size, so you'll have to make some arrangements to use the materials from other manufacturers. You'll also have to tell the printer what the filament type is since there won't be a chip for it to read. I found a new cover for the filament spool opening on Thingiverse that has an opening to feed the filament through, and I mount my filament on a spool holder next to the printer.I have put several spools of 'third party' filament through my 3D45- Mostly PETG. It prints it beautifully.If you're looking for a 3D printer that is going to work right out of the box- With no tinkering or assembly, this is a great choice. If you use just the Dremel Filaments, it will be about as painless a process as 3D printing can be- You will just hit the 'print' button and come back later to take your print off the bed. It is about as easy to use and user friendly as a 3d printer can be. This is where 3D printing needs to go to make it more 'mainstream'... Not everyone enjoys playing with settings and tinkering- Some just want to PRINT!**UPDATE**I've now had this printer up and running for about 3 weeks. I have it going just about 24/7 for about the previous two weeks, producing PETG parts for a machine that I build and sell. It has performed flawlessly, and has produced incredible parts that are both accurate and strong.I decided to try out some other filaments on it, too. The last two pics are items printed with Carbon Fiber PLA. I used SunTop 3d filament, which is available on Amazon. The quality of the prints is incredible- Both of them are right off the build sheet.